Overcoming its earlier divisions on Zika funding, the Senate on Wednesday approved $1.1 billion in research and prevention aid as it passed a bigger appropriations bill to fund the federal government into December.
"We had a small victory today in our ongoing fight against the Zika virus," Nelson said.
"This anti-Zika package rightfully prioritizes Americans in Florida and Puerto Rico," Rubio said. "I'm encouraged that my calls for action have been answered, and that real assistance from the federal government is finally on its way."
The Zika money tucked inside a 10-week stopgap funding measure, the larger $1.1 trillion appropriations package went to the House, with a potentially divisive vote looming in the wake of Friday's end of the current fiscal year.
A large chunk of the $1.1 billion for Zika, less than the $1.9 billion President Barack Obama requested in February, would go to Florida, New York and Puerto Rico, which the virus ravaged during the summer.
The National Institutes for Health would receive more than $160 million of the Zika funds to continue its recently launched first clinical trial for a vaccine and to conduct other research.
The virus is carried primarily by the Aedes aegypti mosquito, but it can also be transmitted through sexual intercourse with an infected partner.
Florida had 904 Zika cases as of Tuesday, 109 of them locally transmitted through mosquitos.
Ninety-one of Florida's Zika infections involved pregnant women, an especially vulnerable group because of the birth defects the virus can cause in newborns.
Microcephaly, which causes infants to be born with abnormally small brains and heads, is the worst known defect.
The Senate vote Wednesday represented a turnaround for Zika funds in the higher chamber. In three earlier summertime votes, Senate Democrats joined by some Republicans rejected stand-alone Zika bills because of extraneous provisions.
The most contentious provision sought to deny any of the new Zika money from going to Planned Parenthood partner clinics in Puerto Rico.
The island has almost 19,500 cases of Zika, some 84 percent of all cases in the United States and far more than any other state or territory.
The divisive Planned Parenthood clause is no longer part of the Zika funding measure in the overall spending bill. The Puerto Rico clinics will be allowed to seek reimbursement for Zika treatment except for abortions, for which federal money has been banned from paying for four decades.
While Nelson, an Orlando Democrat, and Rubio voted for the $1.1 trillion bill, about 1 percent of it for Zika, 11 Republican senators and 10 Democratic senators voted against it.
That bipartisan split among opponents foreshadowed potential pitfalls in the House, which was expected to take up the appropriations measure later Wednesday.
About $400 million of the $1.1 billion in Zika funds is offset in spending cuts to a range of other programs supported by Democratic lawmakers.
Some conservative Republicans, by contrast, want all the new $1.1 trillion in spending offset by cuts elsewhere in the federal budget, which is not achieved.
Democratic Sens. Debbie Stabenow and Gary Peters of Michigan voted against the larger measure because it did not include $500 million they'd requested to clean contaminated water and replace lead pipes in Flint.
Negotiators promised to provide $170 million to Flint in a separate water bill moving through Congress, but that didn't satisfy Stabenow and Peters.
Image credit: Marco Ruiz, Miami Herald