Landon Donovan and Brek Shea were sent home from the U.S. training camp in Miami after team doctors determined their injuries were more serious than anticipated. They were both ruled out of the upcoming World Cup qualifiers at Antigua on Friday and against Guatemala in Kansas City on Tuesday.
U.S. coach Jurgen Klinsmann said no immediate replacements will be added to the roster.
Donovan suffered a knee injury in the LA Galaxy's 2-1 loss on Saturday night. He will return to Los Angeles tonight and be seen by team doctors. He felt much better on Monday and Klinsmann said Tuesday morning he expected Donovan to play, but Dr. Dan Kalbac, the team's Miami-based physician, examined him and suggested he be kept out.
Shea entered camp with an abdominal strain and will be treated in Dallas.
"It's unfortunate for Landon and Brek that they won't be able to play," said Klinsmann. "Landon was very optimistic over the weekend when his knee was feeling much better, but now he needs time to recover. We knew Brek was a question mark coming in, and now we have a clear picture of where he stands. We feel confident that the group we have will get the job done."