Knowshon Moreno suffered a dislocated left shoulder and possible fracture that will keep him out of the lineup at least four weeks but up to eight weeks if there is a serious fracture, a source told The Herald Sunday.
Moreno, the Dolphins running back, injured himself on his first carry of the game.
He gain four yards and did not play the rest of the game.
It was a blow to the Miami running game because last week Moreno rushed for 134 yards on 24 carries. The Dolphins will have to rely on Lamar Miller now. He had 11 carries for 46 yards against the Bills and has gained 105 yards on 22 carries for the season.
The Dolphins used Damien Williams on Sunday, giving him five carries.
It is likely general manager Dennis Hickey will go hunting for a running back tonight or Monday morning.