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South Florida favored son Bob Menendez to face a GOP challenger?

New Jersey Sen. Bob Menendez -- a favorite of Cuban Americans in South Florida -- may face a high-profile GOP challenger. News reports suggest that John Crowley, a New Jersey biotech executive and, as Roll Call notes, "the inspiration for a Hollywood feature film" appears to be considering a run.

Crowley this week disclosed plans to leave his role as CEO of Amicus Therapeutics "to devote more time to interests related to public policy, civic service, and philanthropic endeavors."

Roll Call notes that "GOP officials in Washington, D.C., think Crowley has the personal wealth and biography to become an instant contender in the 2012 race." Crowley helped create a biotech company in part to research a rare disease that threatened the lives of his children. The movie 'Extraordinary Measures,' was based on his quest.